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We are seeking a skilled and driven Principal Scientist with a proven background in tumor immunology, autoimmunity, or both to join our Immunology and Inflammation team. Our team contributes to discovery and development of novel therapeutics in the Cancer Immunology group at Regeneron. You will join a fast pace growing team that develops the next generation of combination immunotherapies, including but not limited to CD3x and co-stimulatory bispecifics antibodies, check point inhibitors, ADC, chemotherapy, vaccine and/or radiation-based combinations. We hope you are excited to have a central role in identifying and developing the right preclinical models necessary not only to understand the way our drugs are working, but also to inform and influence clinical trial study design.

As a Principal Scientist in the Cancer Immunology team, a typical day might include the following:

• Leading the development of in vivo animal (syngeneic and xenogeneic) models relevant to our IO and autoimmune portfolio.

• Independently planning and executing in vivo studies including treatments with injections through various routes (IP, IV, SC), blood and tissue collection for downstream analysis of immune responses.

• Analyzing data using biological and statistical software such as OMIQ, Prism, Excel, etc.

• Collaborating with cross-functional scientists to drive target validation and therapeutic antibody development.

• Delivering impactful presentations to colleagues across our business (preclinical, clinical and translation), including senior leadership.

• Writing protocols and study reports, as well as maintaining accurate electronic records.

• Routinely reviewing relevant literature, attending scientific meetings, and improving expertise in the field of Immunology and Immuno-Oncology.

• Training and managing research associates as needed.

This role might be for you if you:

• Get excited about developing immunotherapies that promote a tumor-specific and durable immune response to eradicate cancer for patients.

• Have a passion for innovation and desire to lead new scientific directions.

• Are a team player with a collaborative spirit.

• Possess excellent communication, organization, and time management skills.

• Independently design and execute experiments, analyze data, and interpret results.

• Experienced with animal model development and experimental design

• Are confident with multitasking and managing multiple projects simultaneously.

In order to be considered for this role, you must have at least a Ph.D. in immunology, immuno-oncology, or a related field and 5+ years of relevant experience or a BS/MS and 15+ years of relevant experience. Must have a strong record of innovation and publication. Proven expertise in T cell biology with experience using mouse tumor and autoimmune models, including high dimensional immunophenotyping, is required. Proficiency with fluorescence microscopy and advanced imaging techniques is a plus.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$126,700.00 - $206,900.00