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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

The Bioassay group at Abbvie South San Francisco, CA is seeking a Scientist II to support the development and evaluation of novel biologics for clinical drugs candidates across different therapeutic areas including oncology, immunology, cell therapy and others. The selected candidate will join the Biologics Analytical Research and Development team which have been involved in the IND submissions of 20+ novel biologic drugs and successful filing of two BLAs. In this lab-based role, you will have unique exposure to drug development experiences, numerous cross-functional interactions, and opportunities to grow and develop in your scientific career.

Responsibilities:

• Development and optimization of complex cell-based functional assays (bioassays) and target-binding potency assays for therapeutic antibodies, complex antibody variants, and antibody-drug conjugates (ADCs).

• Perform potency testing and characterization to support drug development activities and IND submissions.

• Qualify/validate/transfer potency methods to external partners and author technical documents (e.g. methods, protocols and reports) to enable regulatory submission

• Collaborate with the analytical development team to elucidate structure/function molecular characterization and interact cross-functionally with teams from discovery, CMC, QC, and more.

• Develop new techniques, explore new approaches and technologies, perform troubleshooting and optimization experiments, and present your work to various cross-functional teams.

Qualifications

• Degree in chemical biology, biochemistry, cell/molecular biology, or a related field with typically 7+ years (BS) or 5+ years (MS) of relevant industry experience

• Demonstrated experience with current binding potency assay approaches, such as ELISA, flow cytometry, and/or other binding potency assay platforms (i.e. TR-FRET, Octet, etc)

• Demonstrated experience with current bioassay methodologies, such as cytotoxicity assays, reporter gene assays, proliferation assays, primary cell assay and/or ADCC.

• Experience performing cell-based assays, mammalian cell culture and/or target binding potency assays, preferably in a bioassay development group within a Chemistry Manufacturing and Controls (CMC) organization.

• Experience using PRISM, PLA, Softmax Pro, or similar data analysis software.

• Direct experience with biologics, monoclonal antibodies and/or protein therapeutics is a plus

• Direct experience with potency assay optimization and troubleshooting is a plus.

• Proven ability to work in a highly collaborative, cross-functional scientific environment.

• Strong verbal and written communication skills.

• Demonstrated abilities to quickly learn new skills, think independently, and work collaboratively in teams.

• The ideal candidate will be hard-working, self-motivated, detail-oriented, highly organized, and able to adapt quickly to changes.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

Salary: $80,500 - $153,000