Job Information
Amgen Principal Scientist - Computational Biology in South San Francisco, California
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Principal Scientist - Computational Biology
What you will do
Let’s do this. Let’s change the world. The Computational Biology group in the Center for Technology and Innovation (CfTI) within the Precision Medicine organization at Amgen is looking for a highly motivated Computational Biologist with expertise in clinical bioinformatics, biomarker development, assay development, ML algorithms & data science, statistical modeling, handling clinical data sets, and a background in biology and computational sciences. This is a high-visibility, individual contributor role preferring experience within matrixed environments representing the function and requiring the development of methods and familiarity with clinical trials to support the entirety of the clinical portfolio at Amgen, with a focus on Heme-Oncology. This role will play a critical part in advancing Amgen's Precision Medicine initiatives by developing and applying computational methods to support personalized treatment strategies. This includes the development of clinical biomarkers, patient stratification, and the application of knowledge discovery and data mining techniques to uncover novel insights from clinical trial data. In this vital role you will:
Support the development of clinical biomarkers supporting Amgen programs through the formulation and execution of biomarker data analysis
Perform assessment of biochemical coverage, patient stratification, indication selection in Amgen’s early and late clinical development programs and discovery of clinical insights at asset and portfolio levels through the application of knowledge discovery and data mining techniques
Conduct exploratory analysis of clinical trial biomarker/omics data, public/consortium data, and other relevant datasets to uncover novel insights and support clinical programs.
Develop translational informatics analysis methods to enable the analysis of NGS data/Epigenomics assays/single-cell assays from clinical trials
Develop translational informatics analysis workflows in a high-content, multi-omics, multi-modal data domain encompassing genomics, transcriptomics, proteomics, metabolomics and epigenomics domains
Work with biologists, especially in Heme-oncology, to leverage information on targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics and other high content databases.
Champion and exemplify the application of knowledge graphs and modern AI/ML (including generative and transfer learning techniques and task specialization of foundational models) to enable understanding and prediction of clinical endpoints or adverse events (e.g., CRS, Neurotoxicity).
Represent CfTI in some Amgen program/portfolio teams as a biomarker analysis lead.
Participate in diagnostics assay and vendor evaluation and selection by providing inputs from computational perspective
Interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics, and biomarker representatives
Working closely with the Reverse Translation Computational biology lead in support of reverse translational for supporting Amgen programs.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.
Basic Qualifications:
Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of scientific/biopharma industry experience
Or
Master’s degree and 6 years of scientific/biopharma industry experience
Or
Bachelor’s degree and 8 years of scientific/biopharma industry experience
Preferred Qualifications:
PhD in Bioinformatics, Mathematics, Statistics, Computer Science, Computational Biology, or Data Science, with a minor or robust background in Biology
A working knowledge of bioinformatics, applied mathematics, data science to analyze multi-modal, multi-dimensional and large-scale biological data sets such as those from next-generation sequencing DNASeq, RNASeq and proteomics assays
A working knowledge of platforms and readouts utilized for the assessment of clinical biomarkers including flow cytometry, IHC, NGS, immunoassays, imaging, MRD, transcriptional profiling, methylation, and single-cell assays
A good understanding and practical skill of statistics and their use in data analysis for clinical settings
A working knowledge and experience of Machine Learning and AI technologies-experience of applying ML/AI in clinical trial setting is required
Ability to translate biological and medical questions into analytical models providing actionable results
Programming experience in R & Python
Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers and in explorations of mechanisms of action or resistance
Familiarity with assay development and qualification requirements for clinical trial support
Ability to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research community
A strong scientific background with training in genetics and a proven track record of productivity
Strong written and oral communication skills, self-motivation, independence, and leadership
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models, including remote and hybrid work arrangements, where possible
Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
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Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.