Job Information
Merck Senior Scientist - Biophysics in Rahway, New Jersey
Job Description
We are seeking a highly motivated scientist to join our collaborative Biophysics group within the Mass Spectrometry & Biophysics department in Quantitative Biosciences. The Biophysics group is part of a multi-disciplinary team focused on enabling lead identification to advance our drug discovery pipeline across diverse therapeutic areas. We work in a dynamic, discovery research environment and utilize state-of-the-art biophysical techniques to identify novel ligands from multiple modalities such as fragments, small molecules, peptides, and therapeutic proteins.
Candidates should have hands-on experience in biophysical characterization of protein-ligand interactions with the ability to dig deeper into mechanisms-of-action aimed at understanding structure-activity relationships. Candidates who have protein biochemistry experience and have achieved success designing, expressing, purifying, and characterizing complex and challenging protein targets are also strongly encouraged to apply.
We recognize that the diversity of our team is our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.
The successful candidate will join our team of experienced and accomplished colleagues, with responsibilities that include (but are not limited to):
Developing in-depth biophysical and biochemical assays to determine kinetics, thermodynamics, and structural insights into macromolecular interactions.
Establishing comprehensive assays to enable screening campaigns and detailed hit profiling.
Designing and performing experiments with strong attention to detail and documentation in Electronic Laboratory Notebooks.
Partnering with key stakeholders within project team settings, including presenting data at team and department meetings.
Contributing to lab stewardship through safety, compliance, and operational excellence initiatives.
Cultivating an external scientific reputation through publications and presentations.
Qualifications:
Education :
A post-graduate degree in Biophysics or Protein Biochemistry is preferred, but candidates with degrees in other relevant fields are welcome to apply.
Ph.D. +/- relevant postdoctoral experience.
M.Sc. with at least 3 years of job experience in a relevant industrial or academic setting.
Required Skills :
In-depth knowledge of biophysical methodologies for studying protein-ligand interactions with experience in at least one of the following technologies:
Surface plasmon resonance (SPR)
Thermal shift assays (nDSF, TdF)
Microscale Thermophoresis (MST)
Calorimetry (DSC, ITC)
Experience with techniques such as spectroscopy (CD, fluorescence, stopped/quenched flow), DLS, SEC-MALS.
Strong interpersonal skills necessary for a highly collaborative, cross-functional environment.
Excellent communication skills, both verbal and written.
Excellent organizational skills, including the ability to manage multiple projects and to work independently in a collaborative, team-oriented setting.
Proven track record of impactful research and communication, evidenced through peer-reviewed publications and presentations at scientific symposia.
Desirable Skills :
Preference will be given to candidates with experience producing recombinant proteins, including gene design, expression (yeast, bacteria, insect and/or mammalian hosts), purification and characterization.
Experience with purification, structural and/or biophysical characterization of membrane proteins would be a significant advantage.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.
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U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.
Expected salary range:
$111,400.00 - $175,300.00
Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here (https://www.benefitsatmerck.com/) .
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
10%
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
N/A
Job Posting End Date:
07/31/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Job Posting End Date: 07/31/2024
A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID: R301273