University of Pennsylvania Senior Research Specialist - Bonini Lab, Penn Biology in Philadelphia, Pennsylvania
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Posted Job Title
Senior Research Specialist - Bonini Lab, Penn Biology
Job Profile Title
Research Specialist C
Job Description Summary
This position will independently perform laboratory experiments using Drosophila that involved genetics, molecular genetics and genomics; oversee daily management of laboratory experiments, detailed documentation of experiments and processes to ensure regulatory compliance and timely completion of project goals; collaborate with other Senior Scientists and the Principal Investigator (PI) on experimental protocols and research, to meet goals in timely manner; and engaged in tasks to oversee the lab in a lab manager capacity – such as training and overseeing junior lab staff and students; this will also include ordering and maintaining organization of the laboratory.
The Bonini lab specializes in using the genetically tractable model organism, Drosophila, as a tool to understand the molecular basis of disease and disorder of the brain, with a particular focus on degenerative processes including ALS/FTD, TBI and aging. We implement cutting-edge genetic, molecular and cellular approaches to develop and characterize models of these processes to study their molecular basis, with an emphasis on potential translatability to clinical improvement. The lab is looking to hire a new senior research specialist (Research Specialist C) to plan and conduct experiments to meet laboratory research project objectives. This position will independently perform laboratory experiments using Drosophila that involved genetics, molecular genetics and genomics; oversee daily management of laboratory experiments, detailed documentation of experiments and processes to ensure regulatory compliance and timely completion of project goals; collaborate with other Senior Scientists and the Principal Investigator (PI) on experimental protocols and research, to meet goals in timely manner; and engaged in tasks to oversee the lab in a lab manager capacity – such as training and overseeing junior lab staff and students; this will also include ordering and maintaining organization of the laboratory.
The ideal candidate will be a researcher with significant experience with model organism or Drosophila genetics and molecular biology techniques. Familiarity with RNA and ChIP sequencing techniques and bioinformatics data analysis is helpful. Will work on projects investigating the impact of genes on animal brain integrity. Techniques involved include animal husbandry and genetic crosses, molecular genetics for RNA, DNA and chromatin isolation, dissection of animal tissues with immunostaining, histochemistry, molecular genetic techniques, among others. The research specialist will be expected to have mastery of several techniques, master new techniques and independently perform experiments, analyze data, and prepare data summaries. They will work collaboratively in the laboratory, to aid projects of others and train new individuals in the laboratory. The successful candidate will have strong organization and experimental technical skill set plus expertise in writing, presentation, and data analysis.
Duties will include, but are not limited to:
conducting complex studies independently in Drosophila genetics, selecting appropriate strains and selecting appropriate progeny of genetic crosses;
tissue acquisition and processing of Drosophila tissue for molecular genetic analysis including RNA isolation, western immunoblots, realtime PCR, immunoprecipitations;
performing histological and immunohistochemical experiments on various tissues including the brain;
maintaining Drosophila stock lines and creating new stocks;
analyze various Drosophila crosses for effects in various tissues, including in lifespan and tissue processing/histology; (6) keeping detailed laboratory notes, assembling reports and preparing data analysis for development of presentations and reports on research;
keeping laboratory chemical and supply inventory, and ordering supplies as needed.
training new laboratory members in key techniques.
Bachelor's Degree is required and 3 to 5 years of experience, preferable in Drosophila and/or in a molecular genetics and sequencing research setting.
Strong technical skills, plus strong organizational, written, and oral communication skills, and the ability to work independently are required.
Working Conditions Laboratory; Requires extensive safety training Physical Effort Typically sitting at a desk or table; Occasional lifting 25 lb. or less; Intermittently walking, stooping or standing.
The expected salary for this position is: $42,953.00 - $60,134.00
This position is contingent on continued grant funding
Job Location - City, State
Department / School
School of Arts and Sciences
$42,953.00 - $65,861.00
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