Job Information
University of Florida Biological Scientist II in Orange, Florida
Biological Scientist II
Apply now (https://secure.dc4.pageuppeople.com/apply/674/gateway/default.aspx?c=apply&lJobID=532099&lJobSourceTypeID=796&sLanguage=en-us) Job no: 532099
Work type: Staff Full-Time
Location: Orange
Categories: Biology/Life Science
Department: 32040000 - PH-PHARMACODYNAMICS
Classification Title:
Biological Scientist II
Job Description:
Exciting opportunity to work in a combined in vitro pharmacology – medicinal chemistry drug discovery lab and advance small molecules toward new investigational drugs. Research in the PI’s lab seeks to implement improved in vitro cell based systems to better predict human drug efficacy by advancing receptor target-based platforms using receptor-specific and selective ligands and mechanistic pharmacology approaches to understand drug mode of action (e.g. kinetics, allosterism). This position is for a Biological Scientist II to conduct biomedical research in the department of Pharmacodynamics with opportunity to collaborate with medicinal chemists and in vitro and in vivo pharmacologists in the department to advance hit-to-lead small molecules to in vivo efficacy, maintain a database and report structure-activity data.
Job Duties include:
Execute established cell-based assays in 384-well format from standard operating procedures by testing compound and/or peptide activities against receptor target of interest in time-resolved fluorescence energy transfer assays, luminescence signaling and quantifying compound affinity and efficacy in concentration-response using excel and GraphPad prism.
Conduct cell culture of cell lines. This includes propagating human recombinant cells lines and maintaining cell lines in culture under sterile conditions, preparing cells for biological assays and maintaining cryo preserved stocks.
Prepare and carry out experiments with guidance from PI, including setting up organic reaction or analog synthesis in parallel, work up, purify the product, and characterize the structure and purity of the product using various analytical techniques. Modify procedures and experimental design as necessary and with guidance from PI.
Perform compound management. Maintain compound database linking compound structure with assay activities; Manage data and protocols; Present data in written and oral format to Pharmacodynamics group and collaborators; Maintain daily laboratory, manage safety protocols and ordering of supplies; Other duties as assigned.
This position is located at the UF Research and Academic Center at Lake Nona in Orlando, FL. This position is in-person and is not eligible for remote work.
The University of Florida College of Pharmacy values the benefit of having a team that consists of diverse talents, skills, strengths, points of view and experiences. The college is committed to cultivating an environment where everyone is respected for their intrinsic value, and developing the next generation of clinicians and scientists who will positively impact the health of others. We’re committed to creating a working environment where everyone can be heard and recognized for their contributions. In recognition of such efforts, the College of Pharmacy is the 3-time recipient of the Insight into Diversity Health Professions Higher Education Excellence in Diversity Award.
Expected Salary:
$54,000 annually
Employment Benefits include:
Health Insurance: UF participates in state- and university-sponsored benefits programs for individuals, families and domestic partners, and offers voluntary insurance that includes vision, dental, long-term disability and more.
Retirement Options: Attractive options include Florida Retirement System Pension Plan, State University System Optional Retirement Program, Florida Retirement System Investment Plan, and Voluntary Retirement Savings Plan.
Leave: UF Faculty and Staff enjoy a generous paid leave plan as well as access to a sick-leave pool, maternity/paternity leave, and leave payouts.
To learn more visit:hr.ufl.edu/benefits
Minimum Requirements:
Bachelors degree in biology or a related field and three years of experience or Masters degree in biology or a related field with one year of relevant experience.
Preferred Qualifications:
Experience with culturing cell lines. Previous work in synthetic chemistry. Technical experience with working and programming instruments such as dispensers and plate readers. Attention to detail. Previous work with statistical analysis, graphing software and compound databases is highly desirable.
Special Instructions to Applicants:
To be considered, you must upload your cover letter, resume, and list of three professional references.
As a part of our review for research and research support positions, we look for a full CV which includes all professional appointments/engagements, all post-secondary education, and all publications from post-secondary education and all respective dates. Please be sure to not use acronyms in your CV. This CV should include names of entities associated with any projects.
This position is located at the UF Research and Academic Center at Lake Nona in Orlando, FL. This position is in-person and is not eligible for remote work.
This is a time-limited position.
Application must be submitted by 11:55 p.m. (ET) of the posting end date.
Health Assessment Required:No
Advertised: 26 Jun 2024 Eastern Daylight Time
Applications close: 10 Jul 2024 Eastern Daylight Time