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Dr. Shalapour's laboratory is performing work that is at the forefront of establishing a greater understanding of the link between immune response and the lifestyle choices of the individual, such as dietary intake, focusing on hypernutrition and various macro- and micronutrients. Our major aim is to understand the molecular mechanism by which lifestyle choices affect host metabolism, regulate immune cell function, and thereby modulate response to pathogens, cancer development and aging. We aim to develop experimental studies that mimic human dietary choices and utilize our novel animal models and engineered in-vitro models to understand the mechanisms through which diet effects the Gut-Liver-Immune cell axis and subsequently liver and colorectal cancer development. We aim to explore the pathways driving the interactions between altered host metabolism induced by diet and immunometabolism, particularly of cellular and humoral immunity, especially during the development of premalignant lesions.

We accomplish these studies utilizing emerging technologies such as novel animal models, Met-Flow, spatial transcriptomics, Mass spectrometry, microbiome analyses, WGS, and scRNA/ATAC-seq allowing for comprehensive analysis, which when used in conjunction with long term diet intervention, Cre-line targeting, CRIPR/Cas9 technologies and high-parameter flow cytometry serve as powerful tools to enrich our current knowledge. These insights may greatly expand our understanding of how the regulation of nutrient sensing pathways by dietary intervention modulate immunoediting and support tumor development, providing the knowledge needed to advance effective strategies for treatment and prevention. See some example publications: PNAS 2023 May 9;120(19):e2300706120; PNAS , 2021 Feb 23;118(8):e2025840118, Nature . 2015 May 7;521(7550):94-8, J Clin Invest . 2015 Sep;125(9), Nature . 2017 Nov 16;551(7680):340-345.

CANCER BIOLOGY (https://www.mdanderson.org/research/departments-labs-institutes/departments-divisions/cancer-biology.html)

KEY FUNCTIONS

Animal Husbandry

• Mouse colony maintenance and husbandry (Setting up genetic crosses, breeding and weaning).

• Efficiently maintain animal inventory records.

• Mouse genotyping.

• Monitoring health and welfare of animals.

Training

• Assisting and/or training other personnel in the laboratory.

Space and Records

• Maintains laboratory space and scientific records.

• Records and analyzes data and communicates information.

Data and Protocols

• Maintains accurate, detailed records and experimental data and protocols.

Equipment

• Constructs, assembles and operates laboratory apparatus and equipment.

• Other duties as assigned.

Education

Required: Bachelor's degree, major course work in one of the basic sciences.

Experience

Required: No experience.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information

• Requisition ID: 168660

• Employment Status: Full-Time

• Employee Status: Regular

• Work Week: Days

• Minimum Salary: US Dollar (USD) 38,500

• Midpoint Salary: US Dollar (USD) 48,000

• Maximum Salary : US Dollar (USD) 57,500

• FLSA: non-exempt and eligible for overtime pay

• Fund Type: Soft

• Work Location: Onsite

• Pivotal Position: Yes

• Referral Bonus Available?: Yes

• Relocation Assistance Available?: Yes

• Science Jobs: Yes

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